ɑO‐Conotoxin GeXIVA isomers modulate N‐type calcium (Ca_V2.2) channels and inwardly‐rectifying potassium (GIRK) channels via GABA_B receptor activation

αO-Conotoxin GeXIVA is a 28 amino acid peptide derived from the venom of the marine snail Conus generalis. The presence of four cysteine residues in the structure of GeXIVA allows it to have three different disulfide isomers, that is, the globular, ribbon or bead isomer. All three isomers are active at α9α10 nicotinic acetylcholine receptors, with the bead isomer, GeXIVA[1,2], being the most potent and exhibiting analgesic activity in animal...