Original paper
Metabolic memory underlying minimal residual disease in breast cancer
Abstract
Tumor relapse from treatment-resistant cells (minimal residual disease, MRD) underlies most breast cancer-related deaths. Yet, the molecular characteristics defining their malignancy have largely remained elusive. Here, we integrated multi-omics data from a tractable organoid system with a metabolic modeling approach to uncover the metabolic and regulatory idiosyncrasies of the MRD. We find that the resistant cells, despite their...
Paper Details
Title
Metabolic memory underlying minimal residual disease in breast cancer
Published Date
Oct 1, 2021
Journal
Volume
17
Issue
10
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Notes
History