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Review paper

Evolutionary dynamics in Barrett oesophagus: implications for surveillance, risk stratification and therapy

Volume: 19, Issue: 2, Pages: 95 - 111
Published: Nov 2, 2021
Abstract
Cancer development is a dynamic evolutionary process characterized by marked intratumoural heterogeneity at the genetic, epigenetic and phenotypic levels. Barrett oesophagus, the pre-malignant condition to oesophageal adenocarcinoma (EAC), is an exemplary system to longitudinally study the evolution of malignancy. Evidence has emerged of Barrett oesophagus lesions pre-programmed for progression to EAC many years before clinical detection,...
Paper Details
Title
Evolutionary dynamics in Barrett oesophagus: implications for surveillance, risk stratification and therapy
Published Date
Nov 2, 2021
Volume
19
Issue
2
Pages
95 - 111
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