RFA Open as Upfront Treatment for Locally Advanced Pancreatic Cancer: Requiem from a Randomized Controlled Trial

Purpose: Pancreatic adenocarcinoma has a dismal prognosis. Many efforts were directed towards new strategies to treat patients not eligible for radical surgery: local ablation may represent an option for LAPC management but no evidence supports its application. Aim of the study was to compare OS and PFS in patients receiving RFA plus conventional therapy (CHT-RT) with patients receiving only conventional treatment. Methods: This is a...