Synonymous mutations reveal genome-wide levels of positive selection in healthy tissues
Abstract
Genetic alterations under positive selection in healthy tissues have implications for cancer risk. However, total levels of positive selection across the genome remain unknown. Passenger mutations are influenced by all driver mutations, regardless of type or location in the genome. Therefore, the total number of passengers can be used to estimate the total number of drivers-including unidentified drivers outside of cancer genes that are...
Paper Details
Title
Synonymous mutations reveal genome-wide levels of positive selection in healthy tissues
Published Date
Nov 1, 2021
Journal
Volume
53
Issue
11
Pages
1597 - 1605
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