De novo identification of mammalian ciliary motility proteins using cryo-EM
Abstract
Dynein-decorated doublet microtubules (DMTs) are critical components of the oscillatory molecular machine of cilia, the axoneme, and have luminal surfaces patterned periodically by microtubule inner proteins (MIPs). Here we present an atomic model of the 48-nm repeat of a mammalian DMT, derived from a cryoelectron microscopy (cryo-EM) map of the complex isolated from bovine respiratory cilia. The structure uncovers principles of doublet...
Paper Details
Title
De novo identification of mammalian ciliary motility proteins using cryo-EM
Published Date
Nov 1, 2021
Journal
Volume
184
Issue
23
Pages
5791 - 5806.e19
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