Dual roles of AMAP1 in the transcriptional regulation and intracellular trafficking of carbonic anhydrase IX
Abstract
The cell-surface enzyme carbonic anhydrase IX (CAIX/CA9) promotes tumor growth, survival, invasion, and metastasis, mainly via its pH-regulating functions. Owing to its tumor-specific expression, CAIX-targeting antibodies/chemicals are utilized for therapeutic and diagnostic purposes. However, mechanisms of CAIX trafficking, which affects such CAIX-targeting modalities remain unclear. In this study, roles of the AMAP1-PRKD2 pathway, which...
Paper Details
Title
Dual roles of AMAP1 in the transcriptional regulation and intracellular trafficking of carbonic anhydrase IX
Published Date
Jan 1, 2022
Journal
Volume
15
Issue
1
Pages
101258 - 101258
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Notes
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