Translational Oncology
Papers 1,601
1 page of 161 pages (1,601 results)
#1Timothée Olivier (Geneva College)H-Index: 2
#2Vinay Prasad (UCSF: University of California, San Francisco)H-Index: 39
Abstract null null The EMERALD trial was an open label phase 3 trial evaluating elacestrant, the first oral selective estrogen receptor degrader (SERD), as compared to “standard of care”, in ER+/HER2- (hormone receptor positive, no HER2 overexpression) advanced or metastatic breast cancer. null The EMERALD trial restricted the “standard of care” control arm to limited options that may have led to a substandard control arm. We describe how the EMERALD trial protocol allowed different clinically i...
#1Mei HorikawaH-Index: 2
#2Hisataka SabeH-Index: 45
Last. Yasuhito OnoderaH-Index: 13
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Abstract null null Background null The cell-surface enzyme carbonic anhydrase IX (CAIX/CA9) promotes tumor growth, survival, invasion, and metastasis, mainly via its pH-regulating functions. Owing to its tumor-specific expression, CAIX-targeting antibodies/chemicals are utilized for therapeutic and diagnostic purposes. However, mechanisms of CAIX trafficking, which affects such CAIX-targeting modalities remain unclear. In this study, roles of the AMAP1-PRKD2 pathway, which mediates integrin recy...
#1Kaniz Fatema (ISU: Idaho State University)H-Index: 1
#2Jared J. Barrott (ISU: Idaho State University)H-Index: 10
Abstract null null Osteosarcoma is a genetically complex cancer, thus there are increasing efforts to identify biomarkers and regulators within the epigenome that can better predict patient outcomes and provide new therapeutic targets. In this commentary, we have evaluated the work of Peng and colleagues on the identification and function of the signaling axis circ_0088212/miR_520 h/APOA1 in osteosarcoma. We provide the context of how novel it is to demonstrate the anti-tumor functions of APOA1 ...
#1Rajkumar S. Kalra (OIST: Okinawa Institute of Science and Technology)
#2Gaurav S. Soman (University of Pune)
Last. Sharmila A. Bapat (University of Pune)H-Index: 14
view all 9 authors...
The involvement of cancer stem cells (CSCs) in driving tumor dormancy and drug resistance is well established. Most therapeutic regimens however are ineffective in targeting these regenerative populations. We report the development and evaluation of a monoclonal antibody, mAb150, which targets the metastasis associated antigen, Annexin A2 (AnxA2) through recognition of a N-terminal epitope. Treatment with mAb150 potentiated re-entry of CSCs into the cell cycle that perturbed tumor dormancy and f...
#1Laura Kohtamäki (UH: University of Helsinki)H-Index: 2
#2Mariliina Arjama (UH: University of Helsinki)H-Index: 3
Last. Micaela Hernberg (UH: University of Helsinki)H-Index: 20
view all 11 authors...
Therapy options for patients with metastatic melanoma (MM) have considerably improved over the past decade. However, many patients still need effective therapy after unsuccessful immunotherapy, especially patients with BRAF-negative tumors who lack the option of targeted treatment second line. Therefore, the elucidation of efficient and personalized therapy options for these patients is required. In this study, three patient-derived cancer cells (PDCs) were established from NRAS Q61-positive MM ...
#1Yong-Wen Deng (HNU: Hunan Normal University)
#2Yu-Gao Shu (HNU: Hunan Normal University)
Last. Sheng-Li Sun (HNU: Hunan Normal University)
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Abstract null null Background null Glioma is the most common cancer in the central nervous system. Previous studies have revealed that the miR-376 family is crucial in tumour development; however, its detailed mechanism in glioma is not clear. null null null Methods null Cellular mRNA or protein levels of miR-376a, SIRT1, VEGF and YAP1 were detected via qRT–PCR or Western blotting. We analysed the proliferation, angiogenesis and migration abilities of glioma cell lines using colony formation, tu...
#1Ylenia CapodannoH-Index: 2
#2Barbara AltieriH-Index: 17
Last. Joerg Schrader (UHH: Universität Hamburg)H-Index: 7
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Insulinomas are considered rare indolent neuroendocrine neoplasms in human medicine, however when metastases occur no curative treatment is available thus, novel therapies are needed. Recently advances have been made in unraveling the pathophysiology of malignant insulinoma still major challenges hinder the development of a functional model to study them. Canine malignant insulinoma have similar recurrence and a poor prognosis as human malignant insulinoma. Additionally, both human and canine pa...
#1Martin Metzenmacher (University of Duisburg-Essen)H-Index: 8
#2Balazs Hegedus (University of Duisburg-Essen)H-Index: 35
Last. Smiths S Lueong (DKFZ: German Cancer Research Center)H-Index: 5
view all 14 authors...
Abstract null null Background null Radiology is the current standard for monitoring treatment responses in lung cancer. Limited sensitivity, exposure to ionizing radiations and related sequelae constitute some of its major limitation. Non-invasive and highly sensitive methods for early detection of treatment failures and resistance-associated disease progression would have additional clinical utility. null null null Methods null We analyzed serially collected plasma and paired tumor samples from...
#1Hui Du (CAS: Chinese Academy of Sciences)
#2Ozioma Udochukwu Akakuru (CAS: Chinese Academy of Sciences)H-Index: 16
Last. Aiguo Wu (CAS: Chinese Academy of Sciences)H-Index: 53
view all 5 authors...
Abstract null null Magnetic nanoparticles (MNPs) have been extensively researched and implemented in biomedicine for more than half a century due to their non-invasive nature, ease of temporal and spatial manipulation, and considerable biocompatibility. However, the complex magnetic behaviour of MNPs is influenced by several parameters (e.g., particle size, shape, composition, core-shell structure, etc.), among which the amount of transition metal doping plays an important factor. For this reaso...
#2Antonio CiglianoH-Index: 22
Last. Rosa Maria PascaleH-Index: 34
view all 9 authors...
Background null GNMT (glycine N-methyltransferase) is a tumor suppressor gene, but the mechanisms mediating its suppressive activity are not entirely known. null Methods null We investigated the oncosuppressive mechanisms of GNMT in human hepatocellular carcinoma (HCC). GNMT mRNA and protein levels were evaluated by quantitative RT-PCR and immunoblotting. GNMT effect in HCC cell lines was modulated through GNMT cDNA induced overexpression or anti-GNMT siRNA transfection. null Results null GNMT w...
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