Translational Oncology
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#1Jim Abraham (ASU: Arizona State University)H-Index: 1
#2Chadi Nabhan (USC: University of South Carolina)H-Index: 34
Last. David Spetzler (ASU: Arizona State University)H-Index: 14
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#1Selin Kucukyurt (Istanbul University)H-Index: 1
#2Furkan Bahar (Istanbul University)
Last. Ahmet Emre Eskazan (Istanbul University)H-Index: 14
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Abstract The history of low-dose total-body irradiation (LTBI) as a means of radiotherapy for treating malignant tumors can be traced back to the 1920s. Despite this very low total dose, LTBI can induce long-term remissions. Tumor cells are known to change and maintain their own survival and development conditions through autocrine and paracrine signaling. LTBI can change the tumor microenvironment, enhance the infiltration of activated T cells, and trigger inflammatory processes. LTBI-mediated ...
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BACKGROUND Some studies reported stereotactic body radiotherapy (SBRT) has demonstrated superior therapeutic results than conventional radiotherapy. Nevertheless, this statement is controversial and the trial attempting to prove this is underway. We conducted this systemic review and meta-analysis aiming to combine the latest and most complete information about the survival outcomes and toxicities following SBRT for locally advanced pancreatic cancer (LAPC) and borderline resectable pancreatic c...
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#1F. Anthony Greco (Sarah Cannon Research Institute)H-Index: 67
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Abstract Colorectal cancer (CRC) originates as consequence of multiple genetic alterations. Some of the involved genes have been extensively studied (APC, TP53, KRAS, SMAD4, PIK3CA, MMR genes) in highly heterogeneous and poly-metastatic cohorts. However, about 10% of metastatic CRC patients presents with an indolent oligo-metastatic disease differently from other patients with poly-metastatic and aggressive clinical course. Which are the genetic dynamics underlying the differences between oligo-...
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#1Ruofei Yu (Peking Union Medical College)H-Index: 2
#2Hua Bai (Peking Union Medical College)H-Index: 24
Last. Jie Wang (Peking Union Medical College)H-Index: 23
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Abstract null null Tumor protein p53 (TP53) is a tumor suppressor gene and TP53 mutations are associated with poor prognosis in non-small cell lung cancer. However, the in-depth classification of TP53 and its relationship with treatment response and prognosis in epidermal growth factor receptor (EGFR)-mutant tumors treated with EGFR tyrosine kinase inhibitors are unclear. Circulating tumor DNA was prospectively collected at baseline in advanced treatment-naive EGFR-mutant lung adenocarcinoma pat...
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#1Wei Ba (Chinese PLA General Hospital)H-Index: 3
#2Rui Wang (Chinese PLA General Hospital)H-Index: 4
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Abstract null null Background null Deep learning has the potential to improve diagnostic accuracy and efficiency in medical image recognition. In the current study, we developed a deep learning algorithm and assessed its performance in discriminating melanoma from nevus using whole-slide pathological images (WSIs). null null null Methods null The deep learning algorithm was trained and validated using a set of 781 WSIs (86 melanomas, 695 nevi) from PLA General Hospital. The diagnostic performanc...
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#1Min Cheng (Zunyi Medical College)
#2Xiaolin Ye (CQMU: Chongqing Medical University)
Last. Feiji Sun (Zunyi Medical College)
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We aimed to explore the role and mechanism of SOS1 (Son of sevenless homolog 1) in malignant behaviors of epithelial ovarian cancer (EOC) cells Hey with high metastatic potential. Firstly, compared with Hey-WT (wild type) and Hey-NT (none targeted) cells, Hey-SOS1i cells showed decreased polarities, disorders in cytoskeleton arrangement. Numbers of transwell migrated, invaded, intravasation cells and extravasated cells were decreased significantly. Hey-NT cells and Hey-SOS1i cells were employed ...
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#1Kyung Joo Cho (Yonsei University)H-Index: 6
#2Sun Yeong Shin (Yonsei University)
Last. Simon Weonsang Ro (Kyung Hee University)
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Abstract null null Hepatocellular Carcinoma (HCC) is the most common type of primary liver cancer in adults and a leading cause of cancer-related deaths worldwide. Studies have shown that autophagy is significantly involved in carcinogenesis, in particular, driven by activated RAS signaling. Autophagy related 7 (Atg7) is a critical component for the formation of autophagosome and required for autophagy processes. We investigated the role of autophagy in RAS-driven tumorigenesis in the liver, via...
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