A randomized clinical study evaluating effects of high-intensity interval training on myocardial microvascular dysfunction

Background Myocardial microvascular function assessed with the Index of Microcirculatory Resistance (IMR) after heart transplantation (HTx) predicts the development of cardiac allograft vasculopathy (CAV) and adverse long-term outcome. This study aimed to evaluate the otherwise beneficial effects of high-intensity interval training (HIT) on microvascular dysfunction development. Methods Eighty-one de novo HTx patients were randomized to nine...