Multiscale and integrative single-cell Hi-C analysis with Higashi

Volume: 40, Issue: 2, Pages: 254 - 261
Published: Oct 11, 2021
Abstract
Single-cell Hi-C (scHi-C) can identify cell-to-cell variability of three-dimensional (3D) chromatin organization, but the sparseness of measured interactions poses an analysis challenge. Here we report Higashi, an algorithm based on hypergraph representation learning that can incorporate the latent correlations among single cells to enhance overall imputation of contact maps. Higashi outperforms existing methods for embedding and imputation of...
Paper Details
Title
Multiscale and integrative single-cell Hi-C analysis with Higashi
Published Date
Oct 11, 2021
Volume
40
Issue
2
Pages
254 - 261
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