Nature Biotechnology
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#1Mary V. Arrastia (California Institute of Technology)H-Index: 1
#2Joanna W. Jachowicz (California Institute of Technology)H-Index: 2
Last. Mitchell Guttman (California Institute of Technology)H-Index: 41
view all 9 authors...
Although three-dimensional (3D) genome organization is central to many aspects of nuclear function, it has been difficult to measure at the single-cell level. To address this, we developed 'single-cell split-pool recognition of interactions by tag extension' (scSPRITE). scSPRITE uses split-and-pool barcoding to tag DNA fragments in the same nucleus and their 3D spatial arrangement. Because scSPRITE measures multiway DNA contacts, it generates higher-resolution maps within an individual cell than...
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#1Stefan A. Schattgen (St. Jude Children's Research Hospital)H-Index: 13
#2Kate Guion (Fred Hutchinson Cancer Research Center)
Last. Philip Bradley (UW: University of Washington)H-Index: 32
view all 8 authors...
Links between T cell clonotypes, as defined by T cell receptor (TCR) sequences, and phenotype, as reflected in gene expression (GEX) profiles, surface protein expression and peptide:major histocompatibility complex binding, can reveal functional relationships beyond the features shared by clonally related cells. Here we present clonotype neighbor graph analysis (CoNGA), a graph theoretic approach that identifies correlations between GEX profile and TCR sequence through statistical analysis of GE...
1 CitationsSource
#1Loske J (Charité)
#2J. Röhmel (Humboldt University of Berlin)H-Index: 5
Last. Anke Seegebarth (Charité)H-Index: 2
view all 23 authors...
Children are consistently reported to have reduced SARS-CoV-2 infection rates and a substantially lower risk for developing severe COVID-19. However, the molecular mechanisms underlying protection against COVID-19 in younger age groups remain widely unknown. Here, we systematically characterized the single-cell transcriptional landscape in the upper airways in SARS-CoV-2 negative and age-matched SARS-CoV-2 positive children (n=42) and corresponding samples from adults (n=44), covering an age ran...
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#1John D. Roback (Emory University)H-Index: 41
#2Erika A. Tyburski (Georgia Institute of Technology)H-Index: 5
Last. Mark D. GonzalezH-Index: 2
view all 37 authors...
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#1Nicolas Cardozo (UW: University of Washington)H-Index: 1
#2Karen Zhang (UW: University of Washington)H-Index: 1
Last. Jeff Nivala (UW: University of Washington)H-Index: 9
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Detection of specific proteins using nanopores is currently challenging. To address this challenge, we developed a collection of over twenty nanopore-addressable protein tags engineered as reporters (NanoporeTERs, or NTERs). NTERs are constructed with a secretion tag, folded domain and a nanopore-targeting C-terminal tail in which arbitrary peptide barcodes can be encoded. We demonstrate simultaneous detection of up to nine NTERs expressed in bacterial or human cells using MinION nanopore sensor...
1 CitationsSource
#1Tetsuya Nagata (Tokyo Medical and Dental University)H-Index: 23
#2Chrissa A. DwyerH-Index: 1
Last. Takashi Ishii (Tokyo Medical and Dental University)H-Index: 3
view all 24 authors...
Achieving regulation of endogenous gene expression in the central nervous system (CNS) with antisense oligonucleotides (ASOs) administered systemically would facilitate the development of ASO-based therapies for neurological diseases. We demonstrate that DNA/RNA heteroduplex oligonucleotides (HDOs) conjugated to cholesterol or α-tocopherol at the 5′ end of the RNA strand reach the CNS after subcutaneous or intravenous administration in mice and rats. The HDOs distribute throughout the brain, spi...
1 CitationsSource
#1Doria R. Gordon (Environmental Defense Fund)H-Index: 29
#2Gregory Jaffe (Center for Science in the Public Interest)H-Index: 3
Last. Melissa D. Ho (WWF: World Wide Fund for Nature)
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1 CitationsSource
#1Larsson Omberg (Sage Bionetworks)H-Index: 29
#2Elias Chaibub Neto (Sage Bionetworks)H-Index: 17
Last. Samuel M. Goldman (UCSF: University of California, San Francisco)H-Index: 27
view all 22 authors...
Remote health assessments that gather real-world data (RWD) outside clinic settings require a clear understanding of appropriate methods for data collection, quality assessment, analysis and interpretation. Here we examine the performance and limitations of smartphones in collecting RWD in the remote mPower observational study of Parkinson’s disease (PD). Within the first 6 months of study commencement, 960 participants had enrolled and performed at least five self-administered active PD symptom...
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Chinese upstart companies and IT goliaths hope to turn country’s artificial intelligence prowess into world-leading drug innovation. Do they have an edge over Western players?
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