Antisense oligonucleotides: absorption, distribution, metabolism, and excretion

Antisense oligonucleotides (ASOs) have emerged as a promising novel drug modality that aims to address unmet medical needs. A record of six ASO drugs have been approved since 2016, and more candidates are in clinical development. ASOs are the most advanced class within the RNA-based therapeutics field.This review highlights the two major backbones that are currently used to build the most advanced ASO platforms - the phosphorodiamidate...