Expert Opinion on Drug Metabolism & Toxicology
Papers 1,848
1 page of 185 pages (1,848 results)
#1Edmond Atallah (University of Nottingham)H-Index: 1
#2Cristiana Freixo (University of Porto)
Last. Guruprasad P. Aithal (University of Nottingham)H-Index: 63
view all 7 authors...
Introduction Idiosyncratic drug-induced liver injury (DILI) is an unpredictable event, and there are no specific biomarkers that can distinguish DILI from alternative explanations or predict its clinical outcomes. Areas covered This systematic review summarizes the available evidence for all biomarkers proposed to have a role in the diagnosis or prognosis of DILI. Following a comprehensive search, we included all types of studies in humans. We included DILI cases based on any threshold criteria ...
#1Jiangxia Du (ZJU: Zhejiang University)H-Index: 5
#2Hao Yan (ZJU: Zhejiang University)H-Index: 8
Last. Peihua Luo (ZJU: Zhejiang University)H-Index: 16
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INTRODUCTION By 1 January 2021, the FDA has approved a total of 62 small-molecule kinase inhibitors (SMKIs). The increasing clinical use of small-molecule kinase inhibitors has led to some side effects, the most common of which is cutaneous toxicity, as reflected by approximately 90% (57 of 62) of the FDA-approved SMKIs have reported treatment-related cutaneous toxicities. Since these cutaneous toxicities may have a crucial influence on the emotional, physical and psychosocial health of the pati...
#1Ian R. Mulrenin (UNC: University of North Carolina at Chapel Hill)
#2Julian E Garcia (UNC: University of North Carolina at Chapel Hill)
Last. Craig R. Lee (UNC: University of North Carolina at Chapel Hill)H-Index: 43
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INTRODUCTION Hypertensive disorders of pregnancy (HDP) are rising in prevalence, and increase risk of adverse maternal and fetal outcomes. Physiologic changes occur during pregnancy that alter drug pharmacokinetics. However, antihypertensive drugs lack pregnancy-specific dosing recommendations due to critical knowledge gaps surrounding the extent of gestational changes in antihypertensive drug pharmacokinetics and underlying mechanisms. AREAS COVERED This review (1) summarizes currently recommen...
#1Denise Türk (Saarland University)H-Index: 3
#2Laura Maria Fuhr (Saarland University)H-Index: 1
Last. Thorsten Lehr (Saarland University)H-Index: 25
view all 8 authors...
Adverse drug reactions (ADRs) are among the leading causes of death, and frequently associated with drug-gene interactions (DGIs). In addition to pharmacogenomic programs for implementation of genetic preemptive testing into clinical practice, mathematical modeling can help to understand, quantify and predict the effects of DGIs in vivo. Moreover, modeling can contribute to optimize prospective clinical drug trial activities and to reduce DGI-related ADRs.Areas covered: Approaches and challenges...
#1Eleni E. Litsa (Rice University)H-Index: 3
#2Payel Das (IBM)H-Index: 23
Last. Lydia E. Kavraki (Rice University)H-Index: 76
view all 3 authors...
Metabolism can be the underlying cause of drug adverse effects and diminished efficacy. Metabolic reactions in the human body, mediated mainly by enzymes, may transform the administered drug into m...
#1Veronica Di Paolo (UNIPD: University of Padua)H-Index: 4
Last. Luigi Quintieri (UNIPD: University of Padua)H-Index: 17
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BACKGROUND Ohno and Colleagues proposed an approach for predicting drug-drug interactions (DDIs) mediated by cytochrome P450 (CYP) 3A4 based on the use of the ratio of the inhibited to non-inhibited area under the plasma concentration time curve (AUC) of substrates to estimate the fraction of the dose metabolized via CYP3A4 (contribution ratio, CR) and the in vivo inhibitory potency of a perpetrator (inhibition ratio, IR). This study evaluated the performance of this approach on DDIs mediated by...
#2Mohamed Badawi (OSU: Ohio State University)H-Index: 9
Last. Abedelnasser Abulrob (National Research Council)H-Index: 21
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INTRODUCTION Antisense oligonucleotides (ASOs) have emerged as a promising novel drug modality that aims to address unmet medical needs. A record of six ASO drugs have been approved since 2016, and more candidates are in clinical development. ASOs are the most advanced class within the RNA-based therapeutics field. AREAS COVERED This review highlights the two major backbones that are currently used to build the most advanced ASO platforms - the phosphorodiamidate morpholino oligomers (PMOs) and ...
#2Heike WeberH-Index: 23
Last. Angelika Erhardt-Lehmann (MPG: Max Planck Society)H-Index: 2
view all 4 authors...
Introduction null Anxiety disorders (AD) are among the most common mental disorders worldwide. Pharmacotherapy, including benzodiazepines, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and tricyclic antidepressants is currently based on 'trial-and-error,' and is effective in a subset of patients or produces partial response only. Recent research proposes that treatment response and tolerability of the drugs are associated with genetic factors. null Areas ...
#1Natalie R. Neumann (Yale University)H-Index: 1
#2David C. Thompson (UM: University of Montana)H-Index: 39
Last. Vasilis Vasiliou (Yale University)H-Index: 68
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Introduction null As the global population ages at an unprecedented rate, the burden of neurodegenerative diseases is expected to grow. Given the profound impact that neurodegenerative diseases like dementia exert on both individuals and society writ large, researchers, physicians, and scientific organizations have cited a need for increased investigation into their treatment and prevention. Recently, both metformin and aspirin have been associated with improved cognitive outcomes. These agents ...
#1Abimael González-Hernández (UNAM: National Autonomous University of Mexico)H-Index: 13
#2Bruno A. Marichal-Cancino (Autonomous University of Aguascalientes)H-Index: 11
Last. Carlos M. Villalón (CINVESTAV)H-Index: 49
view all 3 authors...
Migraine is a prevalent medical condition and the second most disabling neurological disorder. Regarding its pathophysiology, calcitonin gene-related peptide (CGRP) plays a key role, and, consequen...
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