Organoid vs In Vivo Mouse Model: Which is Better Research Tool to Understand the Biologic Mechanisms of Intestinal Epithelium?

See rebuttal on page 193. See counterpoint on page 1. See rebuttal on page 193. See counterpoint on page 1. The mammalian intestinal epithelium consists of the glandular histologic unit, crypts. Crypts have a remarkable self-renewing capacity, and the entire unit is constantly regenerated within several days. The self-renewing capacity is instrumental for homeostasis and critical after intestinal injury, when new crypts must be formed from a...