Cellular and molecular gastroenterology and hepatology
Papers 894
1 page of 90 pages (894 results)
#1Min-Jiao Pang (PRC: China Medical University (PRC))
#2Joseph Burclaff (UNC: University of North Carolina at Chapel Hill)H-Index: 10
Last. Zhenning Wang (MOE: Chinese Ministry of Education)H-Index: 51
view all 9 authors...
The stomach is a complex and physiologically necessary organ, yet large differences in physiology between mouse and human stomachs have impeded translation of physiological discoveries and drug screens performed using murine gastric tissues. Gastric cancer (GC) is a global health threat, with a high mortality rate and limited treatment options. The heterogeneous nature of gastric cancer makes it poorly suited for current "one size fits all" standard treatments. In this review, we discuss the rap...
#1Carmelo Luci (French Institute of Health and Medical Research)H-Index: 20
#2Elodie Vieira (French Institute of Health and Medical Research)H-Index: 1
Last. Antonio Iannelli (French Institute of Health and Medical Research)H-Index: 45
view all 15 authors...
Background & Aims null Spleen tyrosine kinase (SYK) signaling pathway regulates critical processes in innate immunity, but its role in parenchymal cells remains elusive in chronic liver diseases. We investigate the relative contribution of SYK and its substrate c-Abl Src homology 3 domain-binding protein-2 (3BP2) in both myeloid cells and hepatocytes in the onset of metabolic steatohepatitis. null null null Methods null Hepatic SYK-3BP2 pathway was evaluated in mouse models of metabolic-associat...
#1Varsha SinghH-Index: 21
#2Kelli F. Johnson (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 1
Last. Mark Donowitz (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 81
view all 11 authors...
Background & Aims null One of the features of ulcerative colitis (UC) is a defect in the protective mucus layer. This has been attributed to a reduced number of goblet cells (GCs). However, it is not known whether abnormal GC mucus secretion also contributes to the reduced mucus layer. Our aims were to investigate whether GC secretion was abnormal in UC and exists as a long-term effect of chronic inflammation. null null null Methods null Colonoids were established from intestinal stem cells of h...
#1Nobukatsu Horita (UM: University of Michigan)H-Index: 3
#2Theresa M. Keeley (UM: University of Michigan)H-Index: 17
Last. Linda C. Samuelson (UM: University of Michigan)H-Index: 53
view all 7 authors...
Background & Aims null Notch pathway signaling maintains gastric epithelial cell homeostasis by regulating stem cell proliferation and differentiation. We previously identified NOTCH1 and NOTCH2 as the key Notch receptors controlling gastric stem cell function. Here, we identify the niche cells and critical Notch ligand responsible for regulating stem cell proliferation in the distal mouse stomach. null null null Methods null Expression of Notch ligands in the gastric antrum was determined by qu...
#1Su-Hyung Lee (VUMC: Vanderbilt University Medical Center)H-Index: 1
#2Bogun Jang (Jeju National University)H-Index: 2
Last. James R. Goldenring (Vandy: Vanderbilt University)H-Index: 86
view all 9 authors...
Background & aims null Metaplasia in the stomach is highly associated with development of intestinal-type gastric cancer. Two types of metaplasias, spasmolytic polypeptide-expressing metaplasia (SPEM) and intestinal metaplasia (IM) are considered precancerous lesions. However, it remains unclear how SPEM and IM are related. Here, we investigated a new lineage-specific marker for SPEM cells, aquaporin 5 (AQP5), to assist in the identification of these two metaplasias. null Methods null Drug- or H...
#1Feixue Wang (CUHK: The Chinese University of Hong Kong)H-Index: 1
#2Xiang Zhang (CUHK: The Chinese University of Hong Kong)H-Index: 19
Last. Jun Yu (CUHK: The Chinese University of Hong Kong)H-Index: 138
view all 9 authors...
Background & Aims null Hepatic immune microenvironment plays a pivotal role in the development of nonalcoholic steatohepatitis (NASH). However, the role of natural killer (NK) cells, accounting for 10%–20% of liver lymphocytes, in NASH is still unclear. In this study, we aim to investigate the functional significance of NK cells in NASH evolution. null null null Methods null NASH was induced in mice fed methionine- and choline-deficient diet (MCD), choline-deficient high-fat diet (CD-HFD), or hi...
#1Florian P. Reiter (LMU: Ludwig Maximilian University of Munich)H-Index: 10
#2Liangtao Ye (LMU: Ludwig Maximilian University of Munich)H-Index: 3
Last. Renate Artmann (LMU: Ludwig Maximilian University of Munich)H-Index: 7
view all 18 authors...
Background & Aims null Progression of chronic liver disease (CLD) to liver cirrhosis and liver cancer is a major global cause of morbidity and mortality. Treatment options capable of inhibiting progression of liver fibrosis when etiological treatment of CLD is not available or fails have yet to be established. We investigated the role of serine/threonine kinase p70 ribosomal protein S6 kinase (p70S6K) as checkpoint of fibrogenesis in hepatic stellate cells (HSCs) and as target for the treatment ...
#1Shinya Sugimoto (Keio: Keio University)H-Index: 19
#2Toshiro Sato (Keio: Keio University)H-Index: 58
#1Yusuke Yasutomi (Juntendo University)
#2Asako Chiba (Juntendo University)H-Index: 17
Last. Takashi Nagaishi (Tokyo Medical and Dental University)H-Index: 21
view all 11 authors...
Background & Aims null Mucosal-associated invariant T (MAIT) cells are innate-like T cells restricted by major histocompatibility complex-related molecule 1 (MR1) and express a semi-invariant T cell receptor. Previously, we reported the activation status of circulating MAIT cells in patients with ulcerative colitis (UC) was associated with disease activity and that these cells had infiltrated the inflamed colonic mucosa. These findings suggest MAIT cells are involved in the pathogenesis of infla...
#1Sandra Mattu (University of Cagliari)H-Index: 4
#2Patrizia Zavattari (University of Cagliari)H-Index: 22
Last. Maurizio Parola (UNITO: University of Turin)H-Index: 64
view all 14 authors...
Background & Aims null Activation of the kelch-like ECH-associated protein 1 (Keap1)–nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway has been associated with metabolic reprogramming in many tumors, including hepatocellular carcinoma (HCC). However, the contribution of Nrf2 mutations in this process remains elusive. Here, we investigated the occurrence of Nrf2 mutations in distinct models of mouse hepatocarcinogenesis. null null null Methods null HCCs were generated by experimental pro...
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