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Original paper

Distinct Mutation Landscapes Between Acute Myeloid Leukemia With Myelodysplasia-Related Changes and De Novo Acute Myeloid Leukemia

Volume: 157, Issue: 5, Pages: 691 - 700
Published: Sep 8, 2021
Abstract
To explore the distinct mutation profiles between acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) and de novo AML and their relationships with prognosis.Next-generation sequencing of 42 myeloid neoplasm-related genes in 293 newly diagnosed patients with AML.Eighty-four patients had AML-MRC, and 161 patients had de novo AML. The mutation rates of ASXL1 (25% vs 8.7%, P = .001), NRAS (17.9% vs 8.1%, P = .022), PTPN11 (11.9% vs...
Paper Details
Title
Distinct Mutation Landscapes Between Acute Myeloid Leukemia With Myelodysplasia-Related Changes and De Novo Acute Myeloid Leukemia
Published Date
Sep 8, 2021
Volume
157
Issue
5
Pages
691 - 700
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