Proportion of clinically significant prostate cancer diagnosed by systematic template biopsy after negative pre-biopsy multiparametric magnetic resonance imaging and predictive value of prostate-specific antigen density

Biopsy deferral in men with a negative prostate multiparametric magnetic resonance imaging (mpMRI) is gaining popularity in clinical practice, as mpMRI becomes integrated into prostate cancer (PCa) diagnostic pathways.1 However, clinically significant (cs)PCa may be diagnosed at subsequent template biopsy in men with negative pre-biopsy mpMRI.2 This study evaluated the proportion of men with csPCa diagnosis at template biopsy following a...