Early Prediction of Objective Response of Fibrinogen in a Real-World Cohort of Hepatocellular Carcinoma Cases Treated by Programmed Cell Death Receptor-1 and Lenvatinib

Published on Oct 7, 2021in OncoTargets and Therapy4.147
· DOI :10.2147/OTT.S332351
Yanjun Shen3
Estimated H-index: 3
Huige Wang2
Estimated H-index: 2
+ 1 AuthorsWendong Li3
Estimated H-index: 3
#1Soma Ghosh (Weizmann Institute of Science)H-Index: 5
#2Nishanth Belugali Nataraj (Weizmann Institute of Science)H-Index: 7
Last. Yosef Yarden (Weizmann Institute of Science)H-Index: 131
view all 22 authors...
Summary Cancer immunotherapy focuses on inhibitors of checkpoint proteins, such as programmed death ligand 1 (PD-L1). Unlike RAS-mutated lung cancers, EGFR mutant tumors have a generally low response to immunotherapy. Because treatment outcomes vary by EGFR allele, intrinsic and microenvironmental factors may be involved. Among all non-immunological signaling pathways surveyed in patients’ datasets, EGFR signaling is best associated with high PD-L1. Correspondingly, active EGFRs stabilize PD-L1 ...
#1Jun Young Kim (SKKU: Sungkyunkwan University)H-Index: 1
#2Tae Jun Kim (SMC: Samsung Medical Center)H-Index: 11
Last. Jae J. Kim (SMC: Samsung Medical Center)H-Index: 58
view all 14 authors...
BACKGROUND Gastric gastrointestinal stromal tumors (GISTs) exhibit various degrees of aggression and malignant potential. However, no systematic preoperative evaluation strategy to predict the malignancy potential of gastric GISTs has yet been developed. This study aimed to develop a reliable and easy-to-use preoperative risk-scoring model for predicting high malignancy potential (HMP) gastric GISTs. METHODS The data of 542 patients with pathologically confirmed gastric GISTs who underwent resec...
#6Lin Fan (Xi'an Jiaotong University)H-Index: 17
Hyperfibrinogenemia and cancer-associated systemic inflammatory response are strongly associated with cancer progression and prognosis. We aimed to develop a novel prognostic score (F-SII score) on the basis of preoperative fibrinogen (F) and systemic immunoinflammatory index (SII), and evaluate its predictive value in patients with resectable gastric cancer (GC). Patients diagnosed with GC between January 2012 and December 2016 were reviewed. The F-SII score was 2 for patients with a high fibri...
#1Yihua Wang (CQMU: Chongqing Medical University)H-Index: 3
#2Yu Wang (CQMU: Chongqing Medical University)H-Index: 2
Last. Shengchun Liu (CQMU: Chongqing Medical University)H-Index: 21
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BACKGROUND The aim of this study was to evaluate the relationship between pre-treatment plasma fibrinogen (Fib) level and pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer patients and to assess the role of plasma Fib as a predictive factor. METHODS Data from 1004 consecutive patients with invasive breast cancer who received NAC and subsequent surgery were retrospectively analysed. Both univariate and multivariate analyses based on logistic regression model ...
#1Yi Yang (Peking Union Medical College)H-Index: 3
#2Yi Chen (Shanxi Medical University)H-Index: 3
Last. Qingsheng Fan (Capital Medical University)H-Index: 1
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This study aims to determine the risk factors, patterns, and long-term survival outcomes of late recurrence after radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) within the Milan criteria and develop a nomogram to predict the recurrence-free survival (RFS). This retrospective study included patients with HCC within the Milan criteria, who received RFA at three hospitals in China from January 2011 to December 2016. The clinical variables were assessed by univariate and multivaria...
#2Ryan W. HollowayH-Index: 6
Last. David M. WaismanH-Index: 51
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The tumor microenvironment (TME) is now being widely accepted as the key contributor to a range of processes involved in cancer progression from tumor growth to metastasis and chemoresistance. The extracellular matrix (ECM) and the proteases that mediate the remodeling of the ECM form an integral part of the TME. Plasmin is a broad-spectrum, highly potent, serine protease whose activation from its precursor plasminogen is tightly regulated by the activators (uPA, uPAR, and tPA), the inhibitors (...
#1Xiwen Ye (Sichuan University)H-Index: 2
#2Hai-Jie Hu (Sichuan University)H-Index: 10
Last. Nan-Sheng Cheng (Sichuan University)H-Index: 21
view all 5 authors...
PURPOSE Elevated fibrinogen (Fbg) levels contribute to tumor progression and metastasis. However, little is known regarding the association of the clinicopathological characteristics and the prognosis of hilar cholangiocarcinoma (HC) with plasma fibrinogen. METHODS Data on the plasma Fbg levels, clinicopathological characteristics, and overall survival were retrospectively collected. Plasma fibrinogen concentrations over 4.0 g/L were classified as hyperfibrinogen, elevated fibrinogen, or abnorma...
#1Yujie Liang (SYSU: Sun Yat-sen University)H-Index: 14
#2Xue-ying Mei (SYSU: Sun Yat-sen University)H-Index: 1
Last. Gui-qing Liao (SYSU: Sun Yat-sen University)H-Index: 20
view all 7 authors...
Background The relationship between cancer and coagulation has been intensively studied in recent years; however, the effects of coagulation factors on oral squamous cell carcinoma (OSCC) have rarely been reported. This study aimed to investigate the relationship between preoperative D-dimer (DD), fibrinogen (FIB), platelets (PLT) and OSCC, as well as the prognostic value of DD, FIB and PLT in OSCC. Methods We retrospectively investigated a total of 202 patients with OSCC treated at Guanghua Hos...
#1Josep M. Llovet (University of Barcelona)H-Index: 123
#2Augusto Villanueva (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 62
Last. Lewis R. Roberts (Mayo Clinic)H-Index: 86
view all 13 authors...
: Proper trial design is critical for the success of clinical investigations. Hepatocellular carcinoma (HCC) is a complex disease that has several unique properties. In 2008, after the approval of sorafenib, a panel of experts proposed guidelines for trial design and endpoints in HCC that have been instrumental during the last decade and provided a framework to allow an homogeneous analysis of reported investigations. Since then, several phase III studies have been reported and novel challenges ...
#1Jinzhang ChenH-Index: 3
#2Xiaoyun HuH-Index: 4
Last. Guosheng Yuan (Southern Medical University)H-Index: 5
view all 10 authors...
Background The clinical significance of programmed cell death protein-1 (PD-1)-targeted immunotherapy in Chinese patients is understudied. We thus aimed to evaluate the safety and efficacy of PD-1 inhibitors with toripalimab, camrelizumab or sintilimab for Chinese hepatocellular carcinoma (HCC) patients in a real-life cohort. Methods We analysed hepatitis B virus (HBV)-associated HCC patients treated with toripalimab, camrelizumab, or sintilimab in a retrospective single-center cohort from Novem...
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