Fission yeast RNA‐binding proteins Puf2 and Puf4 are involved in repression of ferrireductase Frp1 expression in response to iron

This study identifies a post‐transcriptional mechanism of iron uptake regulation by Puf2 and Puf4 of the Pumilio and FBF (Puf) family of RNA‐binding proteins in Schizosaccharomyces pombe . Cells expressing Puf2 and Puf4 stimulate decay of the frp1 + mRNA encoding a key enzyme of the reductive iron uptake pathway. Results consistently showed that frp1 + mRNA is stabilized in puf2Δ puf4Δ mutant cells under iron‐replete conditions. As a result,...