Sertraline for Functional Recovery After Acute Ischemic Stroke: A Prospective Observational Study

Background: Neuroprotective and neurorestorative effects have been postulated for selective serotonin-reuptake inhibitors (SSRI). We hypothesized that sertraline, which is characterized by less severe adverse effects and more stable pharmacokinetics than classic SSRI, is associated with improved functional recovery in acute ischemic stroke patients with motor deficits. Methods: Prospective observational study of consecutive acute ischemic stroke...