Review paper
Mechanism, Functions, and Diagnostic Relevance of FXII Activation by Foreign Surfaces
Abstract
Factor XII (FXII) is a serine protease zymogen produced by hepatocytes and secreted into plasma. The highly glycosylated coagulation protein consists of six domains and a proline-rich region that regulate activation and function. Activation of FXII results from a conformational change induced by binding ("contact") with negatively charged surfaces. The activated serine protease FXIIa drives both the proinflammatory kallikrein-kinin pathway and...
Paper Details
Title
Mechanism, Functions, and Diagnostic Relevance of FXII Activation by Foreign Surfaces
Published Date
Sep 30, 2021
Journal
Volume
41
Issue
06
Pages
489 - 501
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