Papers 2,253
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#1Samer Al Said (University Hospital Heidelberg)H-Index: 4
#2Michael Ellscheid (University Hospital Heidelberg)
Last. Norbert Frey (University Hospital Heidelberg)H-Index: 43
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The prevention of atherothrombotic events is the primary goal in the treatment of patients with arteriosclerotic disorders. Despite recent improvements in the management of coronary artery disease (CAD) with revascularization techniques and antiplatelet therapy, some patients remain at risk of recurrent cardiovascular events. This could be related to additional thrombin generation. As a result, there has been interest in developing novel therapies to prevent thromboembolic events, targeting thro...
#1Anne-Katrin Rohlfing (University of Tübingen)H-Index: 1
#2Dominik Rath (University of Tübingen)H-Index: 17
Last. Meinrad Gawaz (University of Tübingen)H-Index: 96
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In 2019 first reports about a new human coronavirus emerged, which causes common cold symptoms as well as acute respiratory distress syndrome. The virus was identified as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and severe thrombotic events including deep vein thrombosis, pulmonary embolism, and microthrombi emerged as additional symptoms. Heart failure, myocardial infarction, myocarditis, and stroke have also been observed. As main mediator of thrombus formation, platelets b...
#2Emmanuella Guenova (UNIL: University of Lausanne)H-Index: 22
Hypercoagulability and vascular injury, which characterize morbidity in COVID-19 disease, are frequently observed in the skin. Several pathomechanisms, such as inflammation caused by angiotensin-converting enzyme 2-mediated uptake into endothelial cells or SARS-CoV-2-initiated host immune responses, contribute to microthrombus formation and the appearance of vascular skin lesions. Besides pathophysiologic mechanisms observed in the skin, this review describes the clinical appearance of cutaneous...
#1Jürgen Koscielny (Charité - University Medicine Berlin)H-Index: 19
#2Christoph SuckerH-Index: 1
#1Martin Duckheim (University of Tübingen)H-Index: 5
#2Jürgen Schreieck (University of Tübingen)H-Index: 10
Since the coronavirus disease (COVID-19) pandemic spread unrelentingly all over the world, millions of cases have been reported. Despite a high number of asymptomatic cases, the course of the disease can be serious or even fatal. The affection of the myocardium, called myocardial injury, is caused by multiple triggers. The occurrence of cardiac arrhythmias in COVID-19 patients with myocardial involvement and a critical course is common. In this review, potential mechanisms, incidence, and treatm...
#1Lars Mizera (University of Tübingen)H-Index: 3
#2Oliver Borst (University of Tübingen)H-Index: 34
Cardiovascular manifestations are frequent in COVID-19 infection and are predictive of adverse outcomes. Elevated cardiac biomarkers are common findings in patients with cardiovascular comorbidities and severe COVID-19 infection. Troponin, inflammatory and thrombotic markers may also improve risk prediction in COVID-19. In our comprehensive review, we provide an overview of the incidence, potential mechanisms and outcome of acute cardiac injury in COVID-19. Thereby, we discuss coagulation abnorm...
#1Meinrad Gawaz (University of Tübingen)H-Index: 96
#2Rüdiger E Scharf (Boston Children's Hospital)H-Index: 2
The COVID-19 pandemic is still threatening us, our patients, and the global health care system. Since the first outbreak at the end of 2019 in China, it became rapidly clear that a new variant of a SARS virus, SARS-CoV-2, is threatening our human society worldwide. Since then, the scientific community has accumulated an incredibly large amount of knowledge about the pathophysiology of this virus, primarily affecting the respiratory tract and, in severe cases, subsequently resulting in acute resp...
#1Sandra Konrath (UHH: Universität Hamburg)H-Index: 2
#2Reiner K. Mailer (UHH: Universität Hamburg)H-Index: 12
Last. Thomas Renné (UHH: Universität Hamburg)H-Index: 64
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Factor XII (FXII) is a serine protease zymogen produced by hepatocytes and secreted into plasma. The highly glycosylated coagulation protein consists of six domains and a proline-rich region that regulate activation and function. Activation of FXII results from a conformational change induced by binding ("contact") with negatively charged surfaces. The activated serine protease FXIIa drives both the proinflammatory kallikrein-kinin pathway and the procoagulant intrinsic coagulation cascade, resp...
#1Zlatko PravdicH-Index: 1
#2Mirjana Mitrovic (University of Belgrade)H-Index: 7
Last. Nada Suvajdzic Vukovic (University of Belgrade)H-Index: 7
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Paroxysmal nocturnal haemoglobinuria (PNH) is a rare, acquired clonal haematological disease characterized by complement-mediated haemolysis, bone marrow failure and venous thrombosis. Anticomplement therapy eculizumab improves survival and reduces complications. Severe acute respiratory distress syndrome corona virus 2 (SARS-CoV-2) disease 2019 (COVID-19) is associated with high incidence of both venous and arterial thrombosis in hospitalized patients with pneumonia. Deep venous thrombosis (DVT...
#1Florian Appenzeller (University of Tübingen)H-Index: 1
#2Jörg Schmehl (University of Tübingen)H-Index: 8
Last. Iris Müller (University of Tübingen)H-Index: 21
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In this case report we present a previously healthy 21-year-old male with extensive thromboembolism in the setting of asymptomatic COVID-19 infection and heterozygous factor V Leiden mutation with no additional thrombophilic risk factors.
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