The acid sphingomyelinase/ceramide system in COVID-19
Abstract
Acid sphingomyelinase (ASM) cleaves sphingomyelin into the highly lipophilic ceramide, which forms large gel-like rafts/platforms in the plasma membrane. We showed that SARS-CoV-2 uses these platforms for cell entry. Lowering the amount of ceramide or ceramide blockade due to inhibitors of ASM, genetic downregulation of ASM, anti-ceramide antibodies or degradation by neutral ceramidase protected against infection with SARS-CoV-2. The addition of...
Paper Details
Title
The acid sphingomyelinase/ceramide system in COVID-19
Published Date
Oct 4, 2021
Journal
Volume
27
Issue
1
Pages
307 - 314
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