Molecular characterisation of pancreatic ductal adenocarcinoma withNTRKfusions and review of the literature

The majority of pancreatic ductal adenocarcinomas (PDACs) harbour oncogenic mutations in KRAS with variants in TP53, CDKN2A and SMAD4 also prevalent. The presence of oncogenic fusions including NTRK fusions are rare but important to identify. Here we ascertain the prevalence of NTRK fusions and document their genomic characteristics in a large series of PDAC.Whole genome sequencing and RNAseq were performed on a series of patients with resected...