Signaling Pathways in Proton and Non-proton ASIC1a Activation
Abstract
Acid-sensing ion channels (ASICs) regulate synaptic activities and play important roles in neurodegenerative diseases as well as pain conditions. Classically, ASICs are described as transiently activated by a reduced pH, followed by desensitization; the activation allows sodium influx, and in the case of ASIC1a-composed channels, also calcium to some degree. Several factors are emerging and extensively analyzed as modulators, activating,...
Paper Details
Title
Signaling Pathways in Proton and Non-proton ASIC1a Activation
Published Date
Oct 5, 2021
Volume
15
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