Last. David Choi(UCL Institute of Neurology)H-Index: 4
view all 3 authors...
Olfactory ensheathing cells (OECs) are specialized glia cells of the olfactory system that support the continual regeneration of olfactory neurons throughout adulthood. Owing to their pro-regenerative properties, OECs have been transplanted in animal models of spinal cord injuries (SCI) and trialed in clinical studies on SCI patients. Although these studies have provided convincing evidence to support the continued development of OEC transplantation as a treatment option for the repair of SCI, d...
Last. Ettore Mosca(NRC: National Academies of Sciences, Engineering, and Medicine)H-Index: 13
view all 29 authors...
Glioblastomas (GBM) are the most aggressive tumors originating in the brain. Histopathologic features include circuitous, disorganized and highly permeable blood vessels with intermittent blood flow. Permeable blood vessels may contribute to the inability to direct therapeutic agents to tumor cells. Current known targets for anti-angiogenic therapies provide limited effect in improvement in overall survival of 12 to 15 months following diagnosis. Identification of novel targets for anti-angiogen...
Last. Xia Bi(UMHS: University of Medicine and Health Sciences)H-Index: 2
view all 6 authors...
Ischemic stroke refers to the disorder of blood supply of local brain tissue caused by various reasons. It has high morbidity and mortality worldwide. Astrocytes are the most abundant glial cells in the central nervous system（CNS）. They are responsible for the homeostasis, nutrition and protection of the CNS, and play an important role in the physiological and pathological processes of many nervous system diseases. After stroke injury, astrocytes are activated and play a protective role through ...
#1Jianhong Li(FJUTCM: Fujian University of Traditional Chinese Medicine)H-Index: 2
#2Bingxue Zhang(FJUTCM: Fujian University of Traditional Chinese Medicine)H-Index: 1
Last. Jing Tao(FJUTCM: Fujian University of Traditional Chinese Medicine)H-Index: 29
view all 13 authors...
Aerobic glycolysis (AG), an important pathway of glucose metabolism, is dramatically declined in Alzheimer's disease (AD). AMP-activated protein kinase (AMPK) is a key regulator to maintain the stability of energy metabolism by promoting the process of aerobic glycolysis and regulate glucose metabolism. Interestingly, it has been previously reported that electro-acupuncture (EA) treatment can improve cognitive function in Alzheimer's disease through the enhancement of glucose metabolism. In this...
The nucleus accumbens (NAc) is a forebrain region mediating the positive-reinforcing properties of drugs of abuse, including alcohol. It receives glutamatergic projections from multiple forebrain and limbic regions such as the prefrontal cortex (PFCx) and basolateral amygdala (BLA), respectively. However, it is unknown how NAc medium spiny neurons (MSNs) integrate PFCx and BLA inputs, and how this integration is affected by alcohol exposure. Because progress has been hampered by the inability to...
Background: Women are more affected by stroke than men. This might, in part, be explained by sex differences in stroke pathophysiology. The hemostasis system is influenced by sex hormones and associated with female risk factors for stroke, such as migraine. Aim: To systematically review possible sex differences in hemostatic related factors in patients with ischemic stroke in general, and the influence of migraine on these factors in women with ischemic stroke. Results: We included 24 studies wi...
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies. To learn more, you can find in our Privacy Policy.