Genetics Awakens the Complex Relationship Between Sleep and Psychiatric Disorders.

Published on Nov 1, 2021in Biological Psychiatry13.382
· DOI :10.1016/J.BIOPSYCH.2021.08.017
Gianluca Ursini20
Estimated H-index: 20
(JHUSOM: Johns Hopkins University School of Medicine),
Giovanna Punzi3
Estimated H-index: 3
(Johns Hopkins University)
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Abstract
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Abstract null null Background null A range of sleep disturbances are commonly experienced by patients with psychiatric disorders, and genome-wide genetic analyses have shown some significant genetic correlations between these traits. Here, we applied novel statistical genetic methodologies to better characterize the potential shared genetic architecture between sleep-related phenotypes and psychiatric disorders. null null null Methods null Using the MiXeR method, which can estimate polygenic ove...
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#1Gianluca Ursini (Johns Hopkins University)H-Index: 20
#2Giovanna Punzi (Johns Hopkins University)H-Index: 3
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#1Jivan Khlghatyan (Laval University)H-Index: 6
#2Alesya Evstratova (U of T: University of Toronto)H-Index: 9
Last. Jean-Martin Beaulieu (U of T: University of Toronto)H-Index: 44
view all 10 authors...
The fragile X autosomal homolog 1 (Fxr1) is regulated by lithium and has been GWAS-associated with schizophrenia and insomnia. Homeostatic regulation of synaptic strength is essential for the maintenance of brain functions and involves both cell-autonomous and system-level processes such as sleep. We examined the contribution of Fxr1 to cell-autonomous homeostatic synaptic scaling and neuronal responses to sleep loss, using a combination of gene overexpression and Crispr/Cas9-mediated somatic kn...
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#1Jonathan S. Emens (OHSU: Oregon Health & Science University)H-Index: 19
#2Alec M. BermanH-Index: 5
Last. Steven SheaH-Index: 125
view all 11 authors...
ABSTACT In humans, there is an endogenous, near 24-hour (i.e., circadian) variation in mood with the best mood occurring during the circadian day and the worst mood occurring during the circadian night. Only positive affect, and not negative affect, has been shown to contribute to this circadian rhythm. We discovered a sharp circadian peak in negative affect during the circadian night coincident with a circadian trough in positive affect. These findings may help explain the association of depres...
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Genetic discoveries about human brain development and neuropsychiatric syndromes have changed the landscape of psychiatric research. The genotyping of hundreds of thousands of individuals has ident...
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#7Qiang Chen (Johns Hopkins University)H-Index: 58
eQTL analysis of human brain RNA-seq data targeted to genes within the 10q24.32 schizophrenia-associated locus reveals that the risk SNP in this region is selectively associated with expression of BORCS7 and a human-specific isoform of AS3MT across multiple independent samples. Expression of only the associated AS3MT isoform is higher in tissue from humans with schizophrenia than in healthy controls.
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#1Julia Whinnery (UPenn: University of Pennsylvania)H-Index: 2
#2Nicholas Jackson (SC: University of Southern California)H-Index: 31
Last. Michael A. Grandner (UPenn: University of Pennsylvania)H-Index: 54
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601 Sleep Duration, Race/Ethnicity, and SES—Whinnery et al INTRODUCTION Sleep duration is an important indicator of health. Indeed, many studies have suggested that consistently acquiring sufficient sleep is necessary for the maintenance of good health.1 However, up to 30% of Americans report only obtaining 6 or fewer hours of sleep per night,2 and based on self-report, the average nightly sleep duration in the United States may be declining.3 Both subjectively reported and objectively measured ...
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#1Yvonne Tay (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 22
#2John L. Rinn (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 89
Last. Pier Paolo Pandolfi (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 158
view all 3 authors...
In recent years, numerous studies have documented pervasive transcription across 70–90% of the human genome. This was particularly surprising because less than 2% of the total genome encodes protein-coding genes, suggesting that non-coding RNAs represent most of the human transcriptome. Recent reports indicate that aside from around 21,000 protein-coding genes, the human transcriptome includes about 9,000 small RNAs, about 10,000–32,000 long non-coding RNAs (lncRNAs) and around 11,000 pseudogene...
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It has long been appreciated that sleep problems are common among those with psychiatric disorders. The prevailing view has been that sleep problems are generally symptoms of the associated psychiatric conditions. Consistent with this point of view is that sleep problems are defining features of a number of psychiatric disorders and included among the diagnostic criteria for these conditions.1 However, there are a number of additional ways that psychiatric disorders and sleep are inter-related. ...
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#1Donald L. Bliwise (Emory University)H-Index: 73
#2Terry Young (UW: University of Wisconsin-Madison)H-Index: 76
Disclosure Statement Dr. Bliwise has received research support from GlaxoSmithKline, Sector Medical, and Takeda; has consulted or been an advisory board member for GlaxoSmithKline, Gerson Lehman Group, Neurocrine, Pfizer, Sanofi-Synthelabo, Takeda, Sepracor, Sleep Medicine Institute, and Cephalon; and has participated in speaking engagements for King, School of Sleep Medicine, Sepracor, and Takeda. Dr. Young has participated in speaking engagements for International Life Sciences Institute and I...
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