49. INTEGRATION OF TRANSCRIPTOMIC AND PROTEOMIC DATA TO REFINE POLYGENIC-RISK INFORMED DRUG REPURPOSING CANDIDATES FOR PSYCHOSIS

Among the various biological effects of asbestos such as fibrogenesis and carcinogenesis, we have been focusing on the immunological effects becausesilica (SiO2) and asbestos chemically is a mineral silicate of silica. Observations of the effects of asbestos on CD4+ T cells showed reduction of CXCR3 chemokine receptor and reduced capacity of interferon γ production. In particular, use of theHTLV-1 immortalized human T cell line, MT-2, and cDNA...