577O PRINCE: Interim analysis of the phase Ib study of 177Lu-PSMA-617 in combination with pembrolizumab for metastatic castration resistant prostate cancer (mCRPC)
Abstract
177Lu-PSMA-617 (Lu-PSMA-617) is a radiolabelled small-molecule with established efficacy and safety in mCRPC, that delivers β radiation to tumours expressing PSMA. Pembrolizumab, an anti-programmed death 1 inhibitor, has modest single agent anti-tumour activity in mCRPC. We hypothesise that β radiation can induce tumour cell death that is potentially immunogenic, and that addition of pembrolizumab to Lu-PSMA-617 can improve responses. PRINCE...
Paper Details
Title
577O PRINCE: Interim analysis of the phase Ib study of 177Lu-PSMA-617 in combination with pembrolizumab for metastatic castration resistant prostate cancer (mCRPC)
Published Date
Sep 1, 2021
Journal
Volume
32
Pages
S626 - S627
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