Original paper
Systems approach reveals distinct and shared signaling networks of the four PGE2receptors in T cells
Abstract
Prostaglandin E2 (PGE2) promotes an immunosuppressive microenvironment in cancer, partly by signaling through four receptors (EP1, EP2, EP3, and EP4) on T cells. Here, we comprehensively characterized PGE2 signaling networks in helper, cytotoxic, and regulatory T cells using a phosphoproteomics and phosphoflow cytometry approach. We identified ~1500 PGE2-regulated phosphosites and several important EP1–4 signaling nodes, including PKC, CK2, PKA,...
Paper Details
Title
Systems approach reveals distinct and shared signaling networks of the four PGE2receptors in T cells
Published Date
Oct 5, 2021
Journal
Volume
14
Issue
703
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Notes
History