Science Signaling
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An IL-2 partial agonist that avoids the terminal differentiation of T cells enhances their antitumor activity.
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#1Anna Mari Lone (University of Oslo)H-Index: 1
#2Piero Giansanti (TUM: Technische Universität München)H-Index: 16
Last. Kjetil Taskén (University of Oslo)H-Index: 73
view all 9 authors...
Prostaglandin E2 (PGE2) promotes an immunosuppressive microenvironment in cancer, partly by signaling through four receptors (EP1, EP2, EP3, and EP4) on T cells. Here, we comprehensively characteri...
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#1Alex D. White (University of Pittsburgh)H-Index: 6
#2Karina Peña (University of Pittsburgh)H-Index: 6
Last. Chia-Ling Tu (UCSF: University of California, San Francisco)H-Index: 30
view all 19 authors...
The parathyroid hormone (PTH) type 1 receptor (PTHR) is a class B G protein–coupled receptor (GPCR) that regulates mineral ion, vitamin D, and bone homeostasis. Activation of the PTHR by PTH induce...
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#1Jens Loncke (Katholieke Universiteit Leuven)H-Index: 2
#2Tim Vervliet (Katholieke Universiteit Leuven)H-Index: 15
Last. Geert Bultynck (Katholieke Universiteit Leuven)H-Index: 71
view all 5 authors...
Mutations in WFS1 (which encodes Wolframin, WFS1) and CISD2 (which encodes CDGSH iron sulfur domain 2) result in Wolfram syndrome (WS), a rare genetic disorder that starts with juvenile diabetes an...
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#1Lei Shi (GSU: Georgia State University)H-Index: 9
#2Koby Kidder (GSU: Georgia State University)H-Index: 5
Last. Yuan Liu (GSU: Georgia State University)H-Index: 1
view all 6 authors...
The cytokines interleukin-4 (IL-4) and IL-13 bind to their shared receptor subunit IL-4Rα to direct the alternative activation of macrophages to promote immunosuppression and wound healing. Activat...
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#1J. Rafael Montenegro-Burke (Scripps Research Institute)H-Index: 12
#2Bernard P. Kok (Scripps Research Institute)H-Index: 10
Last. Gary Siuzdak (Scripps Research Institute)H-Index: 88
view all 11 authors...
Untargeted metabolomics of disease-associated intestinal microbiota can detect quantitative changes in metabolite profiles and complement other methodologies to reveal the full effect of intestinal...
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#6Jumpei Ito ('KCL': King's College London)H-Index: 8
#7Ajay M. Shah ('KCL': King's College London)H-Index: 115
Last. Masahiro Ono (Imperial College London)H-Index: 20
view all 10 authors...
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Leptin exerts its physiological effects after transcytosis in tanycytes mediated by the leptin receptor and EGFR.
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#1Guang Yang (USYD: University of Sydney)H-Index: 32
#2Deanne Francis (USYD: University of Sydney)H-Index: 7
Last. David E. James (USYD: University of Sydney)H-Index: 107
view all 9 authors...
Rapamycin extends maximal life span and increases resistance to starvation in many organisms. The beneficial effects of rapamycin are thought to be mediated by its inhibitory effects on the mechani...
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#1Sarah E. Catheline (URMC: University of Rochester Medical Center)H-Index: 2
#2Richard D. Bell (URMC: University of Rochester Medical Center)H-Index: 11
Last. John P. Ketz (URMC: University of Rochester Medical Center)H-Index: 17
view all 13 authors...
Canonical nuclear factor κB (NF-κB) signaling mediated by homo- and heterodimers of the NF-κB subunits p65 (RELA) and p50 (NFKB1) is associated with age-related pathologies and with disease progres...
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