Oncogenic KRAS blockade therapy: renewed enthusiasm and persistent challenges
Abstract
Across a broad range of human cancers, gain-of-function mutations in RAS genes (HRAS, NRAS, and KRAS) lead to constitutive activity of oncoproteins responsible for tumorigenesis and cancer progression. The targeting of RAS with drugs is challenging because RAS lacks classic and tractable drug binding sites. Over the past 30 years, this perception has led to the pursuit of indirect routes for targeting RAS expression, processing, upstream...
Paper Details
Title
Oncogenic KRAS blockade therapy: renewed enthusiasm and persistent challenges
Published Date
Oct 4, 2021
Journal
Volume
20
Issue
1
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