Original paper
Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects
Abstract
Mental disorders are highly comorbid and occur together with physical diseases, which are often considered to arise from separate pathogenic pathways. We observed in alcohol-dependent patients increased serum activity of neutral sphingomyelinase. A genetic association analysis in 456,693 volunteers found associations of haplotypes of SMPD3 coding for NSM-2 (NSM) with alcohol consumption, but also with affective state, and bone mineralisation....
Paper Details
Title
Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects
Published Date
Sep 28, 2021
Journal
Volume
26
Issue
12
Pages
7403 - 7416
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Notes
History