Accounting for Preinvasive Conditions in Analysis of Invasive Cancer Risk: Application to Breast Cancer.

Background null Preinvasive cancer conditions are often actively treated to minimize progression to life-threatening invasive cancers, but this creates challenges for analysis of invasive cancer risk. Conventional methods of treating preinvasive conditions as censoring events or targeting at the composite outcome could both lead to bias. null Methods null We propose two solutions: one that provides exact estimates of risk based on distributional...