Anatomy embroiders function in Purkinje cells.

Published on Oct 1, 2021in Lancet Neurology44.182
· DOI :10.1016/S1474-4422(21)00281-7
David Attwell88
Estimated H-index: 88
Arpan R Mehta7
Estimated H-index: 7
#1Clare Howarth (UBC: University of British Columbia)H-Index: 16
#2Padraig GleesonH-Index: 20
Last. David AttwellH-Index: 88
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The brain's energy supply determines its information processing power, and generates functional imaging signals. The energy use on the different subcellular processes underlying neural information processing has been estimated previously for the grey matter of the cerebral and cerebellar cortex. However, these estimates need reevaluating following recent work demonstrating that action potentials in mammalian neurons are much more energy efficient than was previously thought. Using this new knowl...
#1Nicolas BrunelH-Index: 59
#2Vincent Hakim ('ENS Paris': École Normale Supérieure)H-Index: 44
Last. Boris Barbour ('ENS Paris': École Normale Supérieure)H-Index: 21
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It is widely believed that synaptic modifications underlie learning and memory. However, few studies have examined what can be deduced about the learning process from the distribution of synaptic weights. We analyze the perceptron, a prototypical feedforward neural network, and obtain the optimal synaptic weight distribution for a perceptron with excitatory synapses. It contains more than 50% silent synapses, and this fraction increases with storage reliability: silent synapses are therefore a n...
#1Philippe Isope ('ENS Paris': École Normale Supérieure)H-Index: 23
#2Boris Barbour ('ENS Paris': École Normale Supérieure)H-Index: 21
The cerebellar cortex contains huge numbers of synapses between granule cells and Purkinje cells. These synapses are thought to be a major storage site for information required to execute coordinated movements. To obtain a quantitative description of this connection, we recorded unitary synaptic responses between granule cell and Purkinje cell pairs in adult rat cerebellar slices. Our results are consistent with parallel fiber→Purkinje cell synapses having high release probabilities and modest p...
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