The effect of lamotrigine and other antiepileptic drugs on respiratory rhythm generation in the pre‐Bötzinger complex

Objective Lamotrigine and other sodium‐channel blocking agents are among the most commonly used antiepileptic drugs (AEDs). Because other sodium channel blockers, such as riluzole, can severely alter respiratory rhythm generation during hypoxia, we wanted to investigate if AEDs can have similar effects. This is especially important in the context of sudden unexpected death in epilepsy (SUDEP), the major cause of death in patients suffering from...