TIM4+ adipose tissue-resident macrophages: new modulators of adiposity.

Published on Aug 19, 2021in Nature Reviews Endocrinology28.8
· DOI :10.1038/S41574-021-00554-6
Jin Young Huh (SNU: Seoul National University), Jae Bum Kim (SNU: Seoul National University)
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Abstract
Adipose tissue macrophages (ATMs) have important roles in the regulation of inflammatory responses and insulin resistance in obesity. A new study reports that a subpopulation of ATMs, TIM4+ resident ATMs, modulate adipocyte size via platelet-derived growth factor-CC production during development and diet-induced adipose tissue expansion.
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