Review paper
Polymerase θ Coordinates Multiple Intrinsic Enzymatic Activities during DNA Repair
Abstract
The POLQ gene encodes DNA polymerase θ, a 2590 amino acid protein product harboring DNA-dependent ATPase, template-dependent DNA polymerase, dNTP-dependent endonuclease, and 5′–dRP lyase functions. Polymerase θ participates at an essential step of a DNA double-strand break repair pathway able to join 5′-resected substrates by locating and pairing microhomologies present in 3′-overhanging single-stranded tails, cleaving the extraneous 3′-DNA by...
Paper Details
Title
Polymerase θ Coordinates Multiple Intrinsic Enzymatic Activities during DNA Repair
Published Date
Aug 25, 2021
Journal
Volume
12
Issue
9
Pages
1310 - 1310
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