Assessment of serum cortisol and thyrotropin correlation in euthyroid and subclinical hypothyroid subjects.

Published on Aug 17, 2021in Expert Review of Endocrinology & Metabolism
· DOI :10.1080/17446651.2021.1968829
RESEARCH DESIGN AND METHODS This cross-sectional study was performed on healthy volunteers and those who had been referred with a diagnosis of subclinical hypothyroidism (TSH<10 mIU/L). Subjects with the age of 18-35 years were enrolled. The sera were analyzed for Cortisol, FT4, FT3, TSH, Ani-TPO, and Anti-Tg. RESULTS Final sample of 36 in group A (TSH<2.5), 45 in group B (TSH: 2.5-4.2), and 71 in group C (TSH: 4.3-10) were included. Cortisol levels were significantly different in the three groups, the lowest for the A group and higher for the C group, and the two-to-two difference in the groups was also significant (p < 0.001). There was a positive and significant correlation between cortisol levels with TSH (r = 0.740; p < 0.001). CONCLUSION There was a potential link between TSH and serum cortisol in young people so that with an increase in TSH from 2.5, the serum cortisol level also increases, but this positive correlation in TSH ≤2.5 was not observed.
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