Expert Review of Endocrinology & Metabolism
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#1Jahanzeb MalikH-Index: 4
#2Syed Muhammad Jawad Zaidi (Rawalpindi Medical College)H-Index: 2
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OBJECTIVE: There is an increasing body of literature on the impact of COVID-19 on the pituitary-thyroid axis. Therefore, we conducted a systematic review to assess the prevalence of hypothyroidism in patients with COVID-19. METHODS: A literature review was conducted using LitCOVID for study selection in PubMed and MEDLINE till May 2021. All relevant original articles evaluating thyroid dysfunction were included and information regarding the prevalence of hypothyroid disease in COVID-19 was retri...
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#1Gianfranco Silecchia (Sapienza University of Rome)H-Index: 37
#2Angelo Iossa (Sapienza University of Rome)H-Index: 12
INTRODUCTION Laparoscopic sleeve gastrectomy is the most commonly performed bariatric procedure worldwide; due to its extensive impact and analysis, multiple procedure-related early and late complications have been described. Gastroesophageal reflux and Barrett's esophagus are highly debated issues related to sleeve gastrectomy in long-term follow-up. This review aims to explore the association between sleeve gastrectomy and gastroesophageal reflux in terms of their occurrence, and to analyze th...
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#1Ghazaleh Shimi (Shahid Beheshti University of Medical Sciences and Health Services)
#2Hamid Zand (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 15
Last. Arman Ghorbani (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 5
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Objectives null Subcellular alteration of thyroid hormones (THs) signaling is proposed in many types of cancers. Some studies show deiodinase type 3, as an oncofetal protein, re-expresses in some cancer types. Therefore, we aimed to investigate the product of this enzyme, reverse triiodothyronine (rT3) in serum of newly diagnosed colorectal cancer (CRC) patients. null Methods null In this cross-sectional study, blood from 38 laboratory-confirmed cases was taken, and serum levels of rT3, total T3...
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Introduction null Hand grip strength (HGS) has been determined as a simple and cost effective method for evaluating overall skeletal muscle strength and quality. It has been used in numerous clinical studies to examine the association between skeletal muscle and type 2 diabetes (T2D). Previous studies have shown that HGS is significantly associated with mortality and cardiovascular disease (CVD) in patients with T2D. As the prevalence of T2D has seen a steady increase globally, HGS measurement c...
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RESEARCH DESIGN AND METHODS This cross-sectional study was performed on healthy volunteers and those who had been referred with a diagnosis of subclinical hypothyroidism (TSH<10 mIU/L). Subjects with the age of 18-35 years were enrolled. The sera were analyzed for Cortisol, FT4, FT3, TSH, Ani-TPO, and Anti-Tg. RESULTS Final sample of 36 in group A (TSH<2.5), 45 in group B (TSH: 2.5-4.2), and 71 in group C (TSH: 4.3-10) were included. Cortisol levels were significantly different in the three grou...
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#1Maria Fleseriu (OHSU: Oregon Health & Science University)H-Index: 30
#2Richard J. Auchus (UM: University of Michigan)H-Index: 63
Last. Beverly M. K. Biller (Harvard University)H-Index: 70
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Introduction: Endogenous Cushing's syndrome (CS) is a rare, life-threatening endocrine disorder that is caused by chronic exposure to cortisol overproduction. Levoketoconazole (Recorlev), a 2S, 4R stereoisomer of ketoconazole, is a steroidogenesis inhibitor under investigation for the treatment of CS.Areas covered: This review covers the pharmacology, efficacy, and safety of levoketoconazole for the treatment of patients with endogenous CS.Expert opinion: Based on the preclinical and clinical ph...
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#1Hotaka Ishizu (Hokkaido University)H-Index: 1
#2Kosuke Arita (Hokkaido University)
Last. Norimasa Iwasaki (Hokkaido University)H-Index: 45
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Introduction: Osteoporosis is characterized by the fragility of bones, leading to fractures and, consequently, the deterioration of functional capacity and quality of life. Postmenopausal women, in particular, are prone to osteoporosis and often require anti-osteoporosis treatment. In the last few decades, various anti-osteoporosis drugs have been approved for clinical use. In an aging society, osteoporosis cannot be treated using a single agent; therefore, switching therapy is an important trea...
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#1Nada Alaaraj (Qatar Airways)H-Index: 2
#2Ashraf T Soliman (Alexandria University)H-Index: 32
Last. Alan D. Rogol (UVA: University of Virginia)H-Index: 84
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Malnutrition may be classified as acute or chronic and by severity into mild, moderate, and severe forms. Features of chronic malnutrition include diminished weight gain, stunted growth, mental apa...
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#1Giacomo Voltan (UNIPD: University of Padua)H-Index: 3
#2Marco Boscaro (UNIPD: University of Padua)H-Index: 66
Last. Filippo Ceccato (UNIPD: University of Padua)H-Index: 22
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INTRODUCTION An adrenal incidentaloma (AI) is an adrenal neoplasm incidentally discovered during an imaging unrelated to suspected adrenal disease. The aim of the present review is to offer practical guidance on the multidisciplinary approach of AIs.Areas covered:The prevalence of AI is high in the aging population (up to 5-8%); however, hormonally active or malignant conditions are rare. After the discovery of an AI, it is suggested to assess in parallel if the mass is potentially malignant and...
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#1Thomas M. Barber (Coventry Health Care)H-Index: 24
#2Martin O. Weickert (Coventry Health Care)H-Index: 46
The COVID-19 global pandemic has influenced all of our lives to a degree that typically occurs once per century. An event of such magnitude compels us to utilize ‘pre-COVID-19ʹ and ‘post-COVID-19ʹ ...
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