Original paper
Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model
Abstract
Therapeutic targeting of injuries that require transient restoration of proteins by mRNA delivery is an attractive approach that, until recently, has remained poorly explored. In this study, we examined the therapeutic utility of mRNA delivery for liver fibrosis and cirrhosis. Specifically, we aimed to demonstrate the therapeutic efficacy of human hepatocyte nuclear factor alpha (HNF4A) mRNA in mouse models of fibrosis and cirrhosis.We...
Paper Details
Title
Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model
Published Date
Dec 1, 2021
Journal
Volume
75
Issue
6
Pages
1420 - 1433
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Notes
History