Review paper
Surplus Ceramides: An Added Twist in the Tale of TREM2 and Insulin Resistance
Abstract
Triggering receptor expressed on myeloid cells 2 (TREM2) is highly expressed by innate immune cells and has been implicated in a variety of diseases, including Alzheimer disease, cancer, and diabetes. TREM2 binds a wide array of ligands signaling tissue damage (1), including pathogenic lipids, which can elicit highly variable effects (both in terms of magnitude and direction) on downstream signaling pathways in a ligand-specific manner (2)....
Paper Details
Title
Surplus Ceramides: An Added Twist in the Tale of TREM2 and Insulin Resistance
Published Date
Sep 1, 2021
Journal
Volume
70
Issue
9
Pages
1926 - 1928
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Notes
History