Pollen shells and soluble factors play non-redundant roles in the development of allergic conjunctivitis in mice

We aimed to clarify the role of particulate allergen exposure to the conjunctiva in the development of allergic conjunctivitis.We administered ragweed pollen suspension, pollen extract, pollen shell, particulate air pollutants, and their combinations to the mouse conjunctiva five days a week without prior sensitization. Clinical signs were scored. Histological changes, cellular infiltrations, mRNA expressions, lymph node cell recall responses,...