Ocular Surface
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#1Brian Thompson (Yale University)H-Index: 4
#2Ying Chen (Yale University)H-Index: 11
Last. Vasilis Vasiliou (Yale University)H-Index: 64
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Abstract null null Purpose null The purpose of this study was to elucidate the role and molecular consequences of impaired glutathione (GSH) biosynthesis on eye development. null null null Methods null GSH biosynthesis was impaired in surface ectoderm-derived ocular tissues by crossing Gclcf/f mice with hemizygous Le-Cre transgenic mice to produce Gclcf/f/Le-CreTg/- (KO) mice. Control mice included Gclcf/f and Gclcwt/wt/Le-CreTg/- mice (CRE). Eyes from all mice (at various stages of eye developm...
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#1Reza A Badian (Oslo University Hospital)H-Index: 4
#2Mattias Andréasson (Karolinska University Hospital)H-Index: 2
Last. Neil Lagali (Linköping University)H-Index: 27
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PURPOSE To describe the pattern of the nerves in the inferocentral whorl region of the human corneal subbasal nerve plexus (SBNP) in health and diseases known to affect the subbasal nerves. METHODS Laser-scanning in vivo confocal microscopy (IVCM) was used to image the SBNP bilaterally in 91 healthy subjects, 39 subjects with type 2 diabetes mellitus (T2DM), and 43 subjects with Parkinson's disease (PD). Whorl regions were classified according to nerve orientation relative to age and health/dise...
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#1Jinmiao Li (BCM: Baylor College of Medicine)H-Index: 2
#2Rong Lu (SYSU: Sun Yat-sen University)H-Index: 6
Last. De-Quan Li (BCM: Baylor College of Medicine)H-Index: 64
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PURPOSE To explore the distinct expression and diverse roles of IL-36 cytokines in dry eye disease using an in vitro hyperosmolarity model of human corneal epithelial cells (HCECs). METHODS Primary HCECs were cultured from fresh donor limbal explants. Hyperosmolarity model was established by switching HCECs from isosmotic (312 mOsM) to hyperosmotic medium (350-500 mOsM) alone or with addition of rhIL-36RA or rhIL-38 for 2-48 h. Some cultures were treated with IL-36α (1-10 ng/ml) with or without ...
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#1Saaya Fukase (Juntendo University)H-Index: 1
#2Tomoaki Ando (Juntendo University)H-Index: 11
Last. Nobuhiro Nakano (Juntendo University)H-Index: 20
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Abstract null null Purpose null We aimed to clarify the role of particulate allergen exposure to the conjunctiva in the development of allergic conjunctivitis. null null null Methods null We administered ragweed pollen suspension, pollen extract, pollen shell, particulate air pollutants, and their combinations to the mouse conjunctiva five days a week without prior sensitization. Clinical signs were scored. Histological changes, cellular infiltrations, mRNA expressions, lymph node cell recall re...
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#1Naresh Polisetti (University of Freiburg)H-Index: 11
#2Andreas Gießl (FAU: University of Erlangen-Nuremberg)H-Index: 12
Last. Ursula Schlötzer-Schrehardt (FAU: University of Erlangen-Nuremberg)H-Index: 76
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PURPOSE Limbal melanocytes (LMel) represent essential components of the corneal epithelial stem cell niche and are known to protect limbal epithelial stem/progenitor cells (LEPCs) from UV damage by transfer of melanosomes. Here, we explored additional functional roles for LMel in niche homeostasis, immune regulation and angiostasis. METHODS Human corneoscleral tissues were morphologically analyzed in normal, inflammatory and wound healing conditions. The effects of LMel on LEPCs were analyzed in...
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#1Amrita Mohanty (LVPEI: L V Prasad Eye Institute)H-Index: 2
#2Srikant K. Sahu (LVPEI: L V Prasad Eye Institute)H-Index: 17
Last. Meena Lakhmipathy (SN: Sankara Nethralaya)
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Ocular microsporidiosis comprises two entirely different spectra of disease as keratoconjunctivitis and stromal keratitis. Microsporidial keratoconjunctivitis (MKC) has been increasingly reported in the past two decades, probably due to raised awareness, simpler diagnostic procedures, and a better understanding of the clinical presentation. It is characterized by the presence of raised, coarse, punctate, multifocal, round to oval, greyish-white corneal epithelial lesions which usually evolve int...
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#1Fiona Stapleton (Vision-Sciences, Inc.)H-Index: 67
Abstract null null Infectious keratitis is a rare but potentially severe sight-threatening disease, associated with considerable societal burden, cost and morbidity. This review summarises the most recent evidence for the incidence, risk factors and impact of disease, all of which vary widely according to region, access to health care, socioeconomic and environmental factors, predisposing conditions and causative organisms. The frequency and societal impact of infectious keratitis are significan...
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#1Sonja MertschH-Index: 11
#2Inga Neumann (HHU: University of Düsseldorf)
Last. Stefan SchraderH-Index: 11
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Purpose null Impairment of corneal nerves can lead to neurotrophic keratopathy accompanied with severe ocular surface damage, which due to limited treatment options, can result in severe visual deterioration. This study evaluates a possible new treatment by enhancing the corneal nerve regeneration using a Rho Kinase inhibitor (Y27632). ROCK is known to play an important role in regulating cell morphology, adhesion and motility but little is known about its role in corneal nerve regeneration. nul...
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#1Leyla Yavuz Saricay (Tufts University)
#2Betül N. Bayraktutar (Tufts University)H-Index: 4
Last. Pedram Hamrah (Tufts University)H-Index: 46
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PURPOSE To illustrate that ocular pain may occur in patients with neurotrophic keratopathy (NK) that typically are thought to lack symptoms of discomfort, and that aa subset of these patients may also present with neuropathic corneal pain (NCP). METHOD Retrospective Case series of 7 stage 1 NK patients who presented with concurrent ocular pain, as confirmed by clinical examination, proparacaine challenge test, and in vivo corneal confocal microscopy (IVCM). Records were assessed for results of o...
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#1Yuqiang Bai (UAB: University of Alabama at Birmingham)H-Index: 8
#2William Ngo (UW: University of Waterloo)H-Index: 8
Last. Jason J. Nichols (UAB: University of Alabama at Birmingham)H-Index: 57
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