Original paper
Therapeutic targeting of endoplasmic reticulum stress in acute graft-<i>versus</i>-host disease
Abstract
Acute graft-versus-host disease (GvHD) is a life-threatening complication of allogeneic hematopoietic cell transplantation (allo-HCT), a potentially curative treatment for leukemia. Endoplasmic reticulum (ER) stress occurs when the protein folding capacity of the ER is oversaturated. How ER stress modulates tissue homeostasis in the context of alloimmunity is not well understood. We show that ER stress contributes to intestinal tissue injury...
Paper Details
Title
Therapeutic targeting of endoplasmic reticulum stress in acute graft-<i>versus</i>-host disease
Published Date
Aug 19, 2021
Journal
Volume
107
Issue
7
Pages
1538 - 1554
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Notes
History