Original paper
Mitochondrial DNA variants modulate N-formylmethionine, proteostasis and risk of late-onset human diseases
Abstract
Mitochondrial DNA (mtDNA) variants influence the risk of late-onset human diseases, but the reasons for this are poorly understood. Undertaking a hypothesis-free analysis of 5,689 blood-derived biomarkers with mtDNA variants in 16,220 healthy donors, here we show that variants defining mtDNA haplogroups Uk and H4 modulate the level of circulating N-formylmethionine (fMet), which initiates mitochondrial protein translation. In human cytoplasmic...
Paper Details
Title
Mitochondrial DNA variants modulate N-formylmethionine, proteostasis and risk of late-onset human diseases
Published Date
Aug 23, 2021
Journal
Volume
27
Issue
9
Pages
1564 - 1575