Original paper

Neonatal NaV1.5 channels: pharmacological distinctiveness of a cancer‐related voltage‐gated sodium channel splice variant

Volume: 179, Issue: 3, Pages: 473 - 486
Published: Dec 2, 2021
Abstract
Voltage-gated sodium (NaV ) channels are expressed de novo in carcinomas where their activity promotes invasiveness. Breast and colon cancer cells express the neonatal splice variant of NaV 1.5 (nNaV 1.5), which has several amino acid substitutions in the domain I voltage-sensor compared with its adult counterpart (aNaV 1.5). This study aimed to determine whether nNaV 1.5 channels could be distinguished pharmacologically from aNaV 1.5...
Paper Details
Title
Neonatal NaV1.5 channels: pharmacological distinctiveness of a cancer‐related voltage‐gated sodium channel splice variant
Published Date
Dec 2, 2021
Volume
179
Issue
3
Pages
473 - 486
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