“Glu/GABA-Gln” metabolic loop abnormalities in iminodipropionitrile (IDPN)-induced dyskinetic syndrome

Iminodipropionitrile (IDPN)-induced dyskinetic syndrome is characterized by abnormal repetitive involuntary movements with abnormalities in the neuro-transmission. This study explored the mechanism of glutamate (Glu)/γ-aminobutyric acid (GABA)-glutamine (Gln) metabolic circuit in rat dyskinetic syndrome and the possible regulation mechanism of “tiapride (Tia).” Male Wistar rats were assigned to the control group, dyskinetic syndrome group, and...