Neurological Sciences
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#1M. F. Nassar (Ain Shams University)H-Index: 11
#2Yasmin G. El-Gendy (Ain Shams University)H-Index: 2
Last. Nesrine Radwan (Ain Shams University)H-Index: 4
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BACKGROUND AND AIM OF THE WORK Ketogenic diet (KD) is one of the treatments in drug-resistant epilepsy (DRE). The current study aimed at assessing the effect of KD-induced ketosis on different immunological cells since ketosis is reported to affect neutrophil function. METHODOLOGY We recruited 21 pediatric patients diagnosed with DRE assigned to start KD. Anthropometric measurements, complete blood picture with differential count, phagocytic function, lymphocyte subsets, and IgG estimation were ...
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#1Atul Goel (JIPMER: Jawaharlal Institute of Postgraduate Medical Education and Research)
#2Ramkumar Sugumaran (JIPMER: Jawaharlal Institute of Postgraduate Medical Education and Research)
Last. Sunil K Narayan (JIPMER: Jawaharlal Institute of Postgraduate Medical Education and Research)H-Index: 14
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Parkinson's disease (PD) is a progressive neurodegenerative disease due to the depletion of the neurotransmitter dopamine in basal ganglia. There is a scarcity of available therapies for motor and non-motor symptoms of PD. Zonisamide (ZNS) may be one such potential candidate to alleviate PD symptoms. It was serendipitously found to be useful for PD in a patient with both epilepsy and PD. Since then, there have been many clinical trials, case series, observational studies, and case reports publis...
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#1Tiffany Li (USYD: University of Sydney)H-Index: 5
#2David Mizrahi (USYD: University of Sydney)
Last. Susanna B. Park (USYD: University of Sydney)H-Index: 27
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Chemotherapy-induced peripheral neurotoxicity (CIPN) is a major dose-limiting side effect of many anti-cancer agents, including taxanes, platinums, vinca alkaloids, proteasome inhibitors, immunomodulatory drugs, and antibody-drug conjugates. The resultant symptoms often persist post treatment completion and continue to impact on long-term function and quality of life for cancer survivors. At present, dose reduction remains the only strategy to prevent severe neuropathy, often leading clinicians ...
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#1Dario Ricciardi (Seconda Università degli Studi di Napoli)H-Index: 3
#2Silvia Casagrande (UniFI: University of Florence)H-Index: 1
Last. Gianmarco Abbadessa (Seconda Università degli Studi di Napoli)H-Index: 5
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COVID-19 pandemic has induced an urgent reorganization of the healthcare system to ensure continuity of care for patients affected by chronic neurological diseases including myasthenia gravis (MG). Due to the fluctuating nature of the disease, early detection of disease worsening, adverse events, and possibly life-threatening complications is mandatory. This work analyzes the main unresolved issues in the management of the myasthenic patient, the possibilities offered so far by digital technolog...
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#1Juanjuan Hao (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Keyu Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. Bitao Ma (SJTU: Shanghai Jiao Tong University)
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OBJECTIVE Iminodipropionitrile (IDPN)-induced dyskinetic syndrome is characterized by abnormal repetitive involuntary movements with abnormalities in the neuro-transmission. This study explored the mechanism of glutamate (Glu)/γ-aminobutyric acid (GABA)-glutamine (Gln) metabolic circuit in rat dyskinetic syndrome and the possible regulation mechanism of "tiapride (Tia)." METHODS Male Wistar rats were assigned to the control group, dyskinetic syndrome group, and Tia group. Dyskinetic syndrome was...
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#1Soo-Hyun Park (SHM: Society of Hospital Medicine)
#2Woo Chang Chun (Inha University)
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Literature data reporting SARS-CoV-2 infection in multiple sclerosis (MS) patients recently treated with immunodepleting agents as cladribine and alemtuzumab are very limited. The relationship between iatrogenic immunodeficiency and risk related to SARS-CoV-2 infection and its severe complications is still not clear. Cautiously, the start of immunosuppressant drugs as alemtuzumab and cladribine during the current COVID-19 pandemic is not recommended unless treatment benefits significantly outwei...
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#1Pavel Štourač (Masaryk University)H-Index: 12
#2Jana Bednářová (Masaryk University)H-Index: 2
Last. Martin Vališ (Charles University in Prague)H-Index: 19
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Autoimmune and limbic encephalitides are still rare diseases characterized by rapid diagnostics and treatment development in recent years. The incidence of anti-N-methyl-D- aspartate receptor [NMDAR] encephalitis is about 1.5 per million person per year, and the incidence of paraneoplastic neurological syndromes [PNS] including limbic encephalitis [LE] is about 1.22 per 100 000 person per year (Vogrig et al. J Neurol 267:26-35, 1; Dalmau et al. Ann Neurol 61:25-36, 2). The diagnostic criteria of...
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Last. Sorilla Prey (University of Bordeaux)H-Index: 14
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INTRODUCTION Myasthenia gravis (MG) Lambert-Eaton (LE) overlap syndrome is a rare condition. Here, we describe the first case of MG-LE overlap syndrome revealed by the anti-programmed cell death 1 inhibitor, nivolumab, in a patient treated for metastatic melanoma. CASE Three months after receiving nivolumab and 1 month after brain metastasis radiotherapy, our patient developed generalized fatigue with intermittent ptosis and swallowing difficulty suggesting a myasthenic syndrome. Electromyogram ...
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#1Aysegul Gunduz (Istanbul University)H-Index: 30
#2AC Aktuglu-Zeybek (Istanbul University)H-Index: 2
Last. Meral E. Kiziltan (Istanbul University)H-Index: 10
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Objective null In this study, we performed analysis of brainstem reflexes and movement disorders using surface polymyogram in L-2-hydroxyglutaric aciduria (L2HGA). We also reviewed all cases in the literature with detailed clinical and radiological description to analyze the anatomical correlates of involuntary movements. null Patients and method null We performed surface electromyography of appropriate muscles, long-loop reflexes, and somatosensory evoked potentials and analyzed the neuroimagin...
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