Dimethyl fumarate ameliorates endotoxin-induced acute kidney injury against macrophage oxidative stress.

Background null Characterized by macrophage infiltration, renal inflammation during septic acute kidney injury (AKI) reveals a ubiquitous human health problem. Unfortunately, effective therapies with limited side effects are still lacking. This study is aiming to elucidate the role of Dimethyl fumarate (DMF) in macrophages against oxidative stress of septic AKI. null Methods null Balb/c mice were gavaged by 50 mg/kg DMF then injected with 10...